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The Role of Pin1 in Controls Tumor Cell Proliferation in Mouse Lung Cancer Conditional Model

By Davide De Carlo

University of Milan, Italy

Cell Science

Published: Nov 30, 2017 | pg. no: 1-38

Abstract: There are some pathways that are altered in many tumors, and RB and p53 pathways are two of the most important. These proteins are regulated during carcinogenesis by a phosphorylation mechanism. Ser or Thr followed by Pro are major phosphorylation motifs in the cells but their significance was obscure until the discovery of the PIN1 protein (protein interacting with NIMA (never in mitosis A)-1) ...[Read more]

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