eBooks View all | By AtoZ | By category

MDM2-Mediated Degradation of SIRT6 Phosphorylated by AKT1 Promotes Tumorigenesis and Trastuzumab Resistance in Breast Cancer

By Umadevi Thirumurthi

The University of Texas, M.D. Anderson Cancer Center, USA

Cancer & Oncology

Published: Oct 28, 2016 | pg. no: 1-55

Abstract: Sirtuin6 (SIRT6) is one of the members of the Sirtuin family and functions as a longevity assurance gene by promoting genomic stability. It also regulates various cancer-associated pathways and was recently established as a bonafide tumor suppressor in colon cancer. This suggests that SIRT6 is an attractive target for pharmacological activation in cancer treatment, and hence, identification of pot ...[Read more]

View eBook

Contact Us:

MedCrave Group, Danforth Rd., Edmond, OK 73003
Tel: +1-918-208-0288, Fax: +1-918-514-7616,
Email: ebooks@medcraveonline.org

Follow us

Indexing

google scholar