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Drug Discovery of Anticancer Agents from the Weeds of the Niligiris Using High Throughput Screening Techniques

By Chaitanya MVNL

Jagadguru Sri Shivarathreeshwara University, India

Complementary & Alternative Medicine

ISBN: 978-0-9967956-6-1

Published: Nov 16, 2016 | pg. no: 72

Abstract: Background: Weeds are store houses of complex bioactive secondary compounds which are the lead molecules for the discovery of pharmaceuticals like Adoniside from Adonis vernalis L., Asiaticoside from Centella asiatica , Silymarin from Silybum marianum (L.) Gaertn etc., which proved that weeds are the richest sources of new pharmaceuticals against many resistant diseases like cancer and tuberculosi ...[Read more]

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The Possible Cause of Polio, Post-Polio, CNS, PVIPD, Legionnaires, AIDS and the Cancer Epidemic - Mass Acidic Chemical Poisoning?

By Robert O Young

Universal Medical Imaging Group, USA

Vaccines

Published: Nov 14, 2016 | pg. no: 1-24

Abstract: There is now over 100 years of documented history and research on the Polio virus and whether or not its treatment by inoculation has been successful in eradicating Polio. I am suggesting in this article that there are significant findings based on historical and past and current research, including my own research that the theory of Polio and possibly other modern-day diseases, such as Post-Polio ...[Read more]

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In Silico Studies on HIV-1 Integrase Inhibitors: A Review

By Basheerulla Shaik

National Institute of Technical Teachers Training, India

Proteomics & Bioinformatics

Published: Oct 31, 2016 | pg. no: 1-31

Abstract: Acquired immunodeficiency syndrome (AIDS) is a formidable pandemic that is still creating havoc world-wide. The curative agent of this disease has been found to be a virus called human immunodeficiency virus of type-1 (HIV-1). In the replicative cycle of HIV-1, the integration of the viral DNA into host chromosomes is an essential step that is catalyzed by the enzyme integrase (IN). Inhibition of ...[Read more]

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MDM2-Mediated Degradation of SIRT6 Phosphorylated by AKT1 Promotes Tumorigenesis and Trastuzumab Resistance in Breast Cancer

By Umadevi Thirumurthi

The University of Texas, M.D. Anderson Cancer Center, USA

Cancer & Oncology

Published: Oct 28, 2016 | pg. no: 1-55

Abstract: Sirtuin6 (SIRT6) is one of the members of the Sirtuin family and functions as a longevity assurance gene by promoting genomic stability. It also regulates various cancer-associated pathways and was recently established as a bonafide tumor suppressor in colon cancer. This suggests that SIRT6 is an attractive target for pharmacological activation in cancer treatment, and hence, identification of pot ...[Read more]

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Influence of Seston Quality on Physiological Condition of Mytilus Edulis in Oligotrophic Lagoon

By Réjean Tremblay

Institut des Sciences de la Mer (ISMER), Canada

Aquaculture & Marine Biology

Published: Oct 22, 2016 | pg. no: 1-21

Abstract: ...[Read more]

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