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MDM2-Mediated Degradation of SIRT6 Phosphorylated by AKT1 Promotes Tumorigenesis and Trastuzumab Resistance in Breast Cancer

By Umadevi Thirumurthi

The University of Texas, M.D. Anderson Cancer Center, USA

Cancer & Oncology

Published: Oct 28, 2016 | pg. no: 1-55

Abstract: Sirtuin6 (SIRT6) is one of the members of the Sirtuin family and functions as a longevity assurance gene by promoting genomic stability. It also regulates various cancer-associated pathways and was recently established as a bonafide tumor suppressor in colon cancer. This suggests that SIRT6 is an attractive target for pharmacological activation in cancer treatment, and hence, identification of pot ...[Read more]

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Influence of Seston Quality on Physiological Condition of Mytilus Edulis in Oligotrophic Lagoon

By Réjean Tremblay

Institut des Sciences de la Mer (ISMER), Canada

Aquaculture & Marine Biology

Published: Oct 22, 2016 | pg. no: 1-21

Abstract: ...[Read more]

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Human Health and Environmental Impacts of Pesticides: Epigenetic Responsibility and a Quest for Justice

By Yehia Ibrahim

Assiut University, Egypt

Forensic & Criminology

Published: Oct 19, 2016 | pg. no: 1-24

Abstract: The reasonable certainty of no harm is the ultimate principle upon which all pesticides should be registered and regulated. There is a multitude of reasons or causations that explains any appreciable human-health and environmental impact of pesticides beyond this principle. This review will only shed some light on these causations, but focus mainly on a misconception-based regulatory policy. The ...[Read more]

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The Hops Tethering Complex and the Dynamin Homolog Vps1 Coordinate Distinct Stages in Intracellular Membrane Fusion

By Aditya Kulkarni

UT Southwestern Medical Center, USA

Proteomics & Bioinformatics

Published: Oct 17, 2016 | pg. no: 1-71

Abstract: Cells in almost all eukaryotes ranging from yeast to humans contain membrane-enclosed compartments called organelles. To survive and proliferate, cells must communicate signals within themselves and with their environment and this is achieved through membrane trafficking. It involves generation of a vesicle carrying specific soluble or membrane-anchored cargo from a precursor membrane, transport o ...[Read more]

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Get Free From Medicine by Just Changing Your Habit

By Chaskar Swati G

S.N.D. College of Pharmacy, India

Pharmacy & Pharmacology

Published: Oct 03, 2016 | pg. no: 1-27

Abstract: Habit is behavior of routines that are repeated regularly and tend to occur subconsciously. A habit, from the standpoint of psychology, is a more or less fixed way of thinking, willing, or feeling acquired through previous repetition of a mental experience." “A bad habit is an undesirable behavior pattern.”The different type of human bad habit responsible for disease and disorder such as eatin ...[Read more]

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