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In Silico Studies on HIV-1 Integrase Inhibitors: A Review
By Basheerulla Shaik
National Institute of Technical Teachers Training, India
Published: Oct 31, 2016 | pg. no: 1-31
Abstract: Acquired immunodeficiency syndrome (AIDS) is a formidable pandemic that is still creating havoc world-wide. The curative agent of this disease has been found to be a virus called human immunodeficiency virus of type-1 (HIV-1). In the replicative cycle of HIV-1, the integration of the viral DNA into host chromosomes is an essential step that is catalyzed by the enzyme integrase (IN). Inhibition of ...[Read more]
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MDM2-Mediated Degradation of SIRT6 Phosphorylated by AKT1 Promotes Tumorigenesis and Trastuzumab Resistance in Breast Cancer
By Umadevi Thirumurthi
The University of Texas, M.D. Anderson Cancer Center, USA
Published: Oct 28, 2016 | pg. no: 1-55
Abstract: Sirtuin6 (SIRT6) is one of the members of the Sirtuin family and functions as a longevity assurance gene by promoting genomic stability. It also regulates various cancer-associated pathways and was recently established as a bonafide tumor suppressor in colon cancer. This suggests that SIRT6 is an attractive target for pharmacological activation in cancer treatment, and hence, identification of pot ...[Read more]
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Influence of Seston Quality on Physiological Condition of Mytilus Edulis in Oligotrophic Lagoon
By Réjean Tremblay
Institut des Sciences de la Mer (ISMER), Canada
Published: Oct 22, 2016 | pg. no: 1-21
Abstract: ...[Read more]
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Human Health and Environmental Impacts of Pesticides: Epigenetic Responsibility and a Quest for Justice
By Yehia Ibrahim
Assiut University, Egypt
Published: Oct 19, 2016 | pg. no: 1-24
Abstract: The reasonable certainty of no harm is the ultimate principle upon which all pesticides should be registered and regulated. There is a multitude of reasons or causations that explains any appreciable human-health and environmental impact of pesticides beyond this principle. This review will only shed some light on these causations, but focus mainly on a misconception-based regulatory policy. The ...[Read more]
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The Hops Tethering Complex and the Dynamin Homolog Vps1 Coordinate Distinct Stages in Intracellular Membrane Fusion
By Aditya Kulkarni
UT Southwestern Medical Center, USA
Published: Oct 17, 2016 | pg. no: 1-71
Abstract: Cells in almost all eukaryotes ranging from yeast to humans contain membrane-enclosed compartments called organelles. To survive and proliferate, cells must communicate signals within themselves and with their environment and this is achieved through membrane trafficking. It involves generation of a vesicle carrying specific soluble or membrane-anchored cargo from a precursor membrane, transport o ...[Read more]
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