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The Study of Magnesium Sulphate Vs Diazepam in Eclampsia

By Tariq Masood Khan

Lady Willingdon Hospital, Pakistan

Pediatrics

Published: Jul 18, 2016 | pg. no: 1-41

Abstract: Eclampsia is a life threatening condition with highest mortality and morbidity characterized by uncontrolled hypertension un-consciousness fits albumin urea in the setting the of Pre Eclampsia. Study: An extensive elaborative study carried out from 2005 to 2009, to study the therapeutic and prophylactic role of Magnesium Sulphate and Diazepam in Eclampsia. Study Period: Four Years 2005 to 2009. Objective: To study MgSo4 Vs Diazepam reducing MMR, NMR in Eclampsia. Study Design: This was a comparative study. Total 500 patients of fulminent pre- Eclampsia/Eclampsia were studied included booked / un-booked patients attending Lady Willingdon Hospital were admitted evaluated assessed and put on MgSo4 Vs Diazepam divided in two groups. The results were compared which showed of MgSo4 as superior in efficacy of compared to Diazepam in improving overall mortality morbidity in Eclampsia. Material and Methods: Total 500 patients of Eclampsia admitted and studied in Unit – 2 Lady Willingdon Teaching Hospital of King Edward Medical University Lahore managed in ICU according to a specially design proforma, protocol and were given MgSo4 and Diazepam for control of fits, Hydralazine, Labetalol and Isoket infusions for lowering – blood pressure (MgSO4) A+B. (Diazepam) with multi disciplinary involvement divided in two groups compared and followed up. Results: In Group-A there were 20 mothers and in Group-B 40 mothers died. It was observed that maternal mortality. Was significantly higher in Group-B women as compared to that of Group-A. i.e. (p-value=0.005) In Group-A there were 20 mothers and in Group-B 40 mothers died. It was observed that maternal mortality was significantly higher in Group-B women as compared to that of Group-A. i.e. (p-value=0.005) Conclusion: The comparative study and of role of MgSO4 Vs Diazepam in reducing Mortality, morbidity in maternities, neoneties, efficacy showed the superiorness of Magnesium Sulphate as compared to Diazepam without any doubt.

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