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The Possible Cause of Polio, Post-Polio, CNS, PVIPD, Legionnaires, AIDS and the Cancer Epidemic - Mass Acidic Chemical Poisoning?

By Robert O Young

Universal Medical Imaging Group, USA

Vaccines

Published: Nov 14, 2016 | pg. no: 1-24

Abstract: There is now over 100 years of documented history and research on the Polio virus and whether or not its treatment by inoculation has been successful in eradicating Polio. I am suggesting in this article that there are significant findings based on historical and past and current research, including my own research that the theory of Polio and possibly other modern-day diseases, such as Post-Polio ...[Read more]

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In Silico Studies on HIV-1 Integrase Inhibitors: A Review

By Basheerulla Shaik

National Institute of Technical Teachers Training, India

Proteomics & Bioinformatics

Published: Oct 31, 2016 | pg. no: 1-31

Abstract: Acquired immunodeficiency syndrome (AIDS) is a formidable pandemic that is still creating havoc world-wide. The curative agent of this disease has been found to be a virus called human immunodeficiency virus of type-1 (HIV-1). In the replicative cycle of HIV-1, the integration of the viral DNA into host chromosomes is an essential step that is catalyzed by the enzyme integrase (IN). Inhibition of ...[Read more]

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MDM2-Mediated Degradation of SIRT6 Phosphorylated by AKT1 Promotes Tumorigenesis and Trastuzumab Resistance in Breast Cancer

By Umadevi Thirumurthi

The University of Texas, M.D. Anderson Cancer Center, USA

Cancer & Oncology

Published: Oct 28, 2016 | pg. no: 1-55

Abstract: Sirtuin6 (SIRT6) is one of the members of the Sirtuin family and functions as a longevity assurance gene by promoting genomic stability. It also regulates various cancer-associated pathways and was recently established as a bonafide tumor suppressor in colon cancer. This suggests that SIRT6 is an attractive target for pharmacological activation in cancer treatment, and hence, identification of pot ...[Read more]

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Influence of Seston Quality on Physiological Condition of Mytilus Edulis in Oligotrophic Lagoon

By Réjean Tremblay

Institut des Sciences de la Mer (ISMER), Canada

Aquaculture & Marine Biology

Published: Oct 22, 2016 | pg. no: 1-21

Abstract: Mytilus edulis culture depends on natural plankton with seasonal variations in dietary nutritional value. The microbial communities assimilated by M. edulis in Magdalen Islands lagoons (St. Lawrence Gulf, Canada), are mainly dominated by small heterotrophic eukaryotes, which vary taxonomically and in terms of lipid composition over the growing season. Particular lipids classes and fatty acids foun ...[Read more]

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Human Health and Environmental Impacts of Pesticides: Epigenetic Responsibility and a Quest for Justice

By Yehia Ibrahim

Assiut University, Egypt

Forensic & Criminology

Published: Oct 19, 2016 | pg. no: 1-24

Abstract: The reasonable certainty of no harm is the ultimate principle upon which all pesticides should be registered and regulated. There is a multitude of reasons or causations that explains any appreciable human-health and environmental impact of pesticides beyond this principle. This review will only shed some light on these causations, but focus mainly on a misconception-based regulatory policy. The ...[Read more]

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