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MDM2-Mediated Degradation of SIRT6 Phosphorylated by AKT1 Promotes Tumorigenesis and Trastuzumab Resistance in Breast Cancer
By Umadevi Thirumurthi
The University of Texas, M.D. Anderson Cancer Center, USA
Published: Oct 28, 2016 | pg. no: 1-55
Abstract: Sirtuin6 (SIRT6) is one of the members of the Sirtuin family and functions as a longevity assurance gene by promoting genomic stability. It also regulates various cancer-associated pathways and was recently established as a bonafide tumor suppressor in colon cancer. This suggests that SIRT6 is an attractive target for pharmacological activation in cancer treatment, and hence, identification of pot ...[Read more]
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Influence of Seston Quality on Physiological Condition of Mytilus Edulis in Oligotrophic Lagoon
By Réjean Tremblay
Institut des Sciences de la Mer (ISMER), Canada
Published: Oct 22, 2016 | pg. no: 1-21
Abstract: Mytilus edulis culture depends on natural plankton with seasonal variations in dietary nutritional value. The microbial communities assimilated by M. edulis in Magdalen Islands lagoons (St. Lawrence Gulf, Canada), are mainly dominated by small heterotrophic eukaryotes, which vary taxonomically and in terms of lipid composition over the growing season. Particular lipids classes and fatty acids foun ...[Read more]
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Human Health and Environmental Impacts of Pesticides: Epigenetic Responsibility and a Quest for Justice
By Yehia Ibrahim
Assiut University, Egypt
Published: Oct 19, 2016 | pg. no: 1-24
Abstract: The reasonable certainty of no harm is the ultimate principle upon which all pesticides should be registered and regulated. There is a multitude of reasons or causations that explains any appreciable human-health and environmental impact of pesticides beyond this principle. This review will only shed some light on these causations, but focus mainly on a misconception-based regulatory policy. The ...[Read more]
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The Hops Tethering Complex and the Dynamin Homolog Vps1 Coordinate Distinct Stages in Intracellular Membrane Fusion
By Aditya Kulkarni
UT Southwestern Medical Center, USA
Published: Oct 17, 2016 | pg. no: 1-71
Abstract: Cells in almost all eukaryotes ranging from yeast to humans contain membrane-enclosed compartments called organelles. To survive and proliferate, cells must communicate signals within themselves and with their environment and this is achieved through membrane trafficking. It involves generation of a vesicle carrying specific soluble or membrane-anchored cargo from a precursor membrane, transport o ...[Read more]
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Get Free From Medicine by Just Changing Your Habit
By Chaskar Swati G
S.N.D. College of Pharmacy, India
Published: Oct 03, 2016 | pg. no: 1-27
Abstract: Habit is behavior of routines that are repeated regularly and tend to occur subconsciously. A habit, from the standpoint of psychology, is a more or less fixed way of thinking, willing, or feeling acquired through previous repetition of a mental experience." “A bad habit is an undesirable behavior pattern.”The different type of human bad habit responsible for disease and disorder such as eatin ...[Read more]
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